Method development and analyzing proteins

Transform Your HPLC and UHPLC Method Development Mindset on Analyzing Proteins— Including Monoclonal Antibodies!

A discussion of wide-pore/core-shell technology for monoclonal antibodies, method development considerations with wide-pore/core-shell columns, size exclusion chromatography (SEC) using sub-2 μm particles, and method optimization for SEC. (Webinar sneak peek) Click Here To View Entire Webinar   Introduction Analytical chemists have relied on high performance liquid chromatography (HPLC) columns such as Kinetex® Core-Shell and Luna®…

SPE vs LLE: A Battle of Methods

An Improved Clean Up and Recovery of Pharmaceutical Compounds from Plasma using Strata® -X In one corner, we have liquid-liquid extraction (LLE), which is perhaps the most established clean-up technique used in the chromatography field. Although it has been used for years, newer techniques with improved specificity towards particular analytes, have allowed analysts to improve…

Chiral chromatography pharmaceutical

What is Chiral?

What Exactly Does Chiral Mean? Chirality is a special physical property of a molecule which describes its geometry in three-dimensional space. Chiral molecules commonly consist of a carbon atom attached to four different substituents. The substituents can either be atoms or groups of atoms, but each must differ from the other three for the carbon…

First ALS Drug Approved in Over 2 Decades

A social media sensation has finally paid off. The U.S. Food and Drug Administration (FDA) has recently approved the first drug to combat amyotrophic lateral sclerosis, or ALS, in 22 years. The new drug, Radicava, has shown that it can slow progress of the physical conditions related to the disease by 33%. The ice-bucket challenge was…